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    (2016-01-01) Changes in the Gut Mycome and Microbiome during Necrotizing Enterocolitis-like Murine Intestinal Injury
    Beesems, G. (Geerte)
    INTRODUCTION – Necrotizing enterocolitis (NEC) is a gastrointestinal crisis in the newborn infant. NEC is among the most common and devastating diseases in newborns with a mortality up to 30% and still one of the most difficult to eradicate. NEC is therefore a priority for research. Unfortunately, the pathophysiology of NEC is not completely understood. A multifactorial cause is suggested in previous research, most investigative attention has remained focused on the role of bacterial flora, an....................
    (2016-01-01) Reducing bed rest following inguinal lymph node dissection in melanoma patients.
    Heidema, R. (Rianna)
    Aim: Inguinal lymph node dissection (ILND) in stage III melanoma is accompanied with high morbidity. During time bed rest protocols have been reduced. The aim of the study was to evaluate the effect of reduction of bed rest on wound complications. Methods: Between 1989 and 2014 a total of 245 patients who underwent an ILND were studied. Four chronological groups were formed respectively: group A: ≥ 7 days with Bohler Braun splint, group B: ≥ 7 days without splint, group C: 5 or 6 days and gr....................
    (2016-01-01) Survival and vascular damage in long-term testicular cancer survivors after chemotherapy treatment
    Kruyt, L.M. (Lara)
    BACKGROUNDS: Following the introduction of platinum-based chemotherapy in the late 1970s, testicular cancer (TC) survival rates increased exceedingly. However, chemotherapy-related vascular morbidity is likely to pose a major threat to TC survivors in the long-term. Arterial stiffness, as measured by pulse wave velocity (PWV), may be predictive of cardiovascular morbidity and mortality. Both survival and arterial stiffness have never been assessed in TC survivors who underwent treatment more tha....................
    (2016-01-01) Young Asthma Patients’ Experience and Opinion of the Instruction Inhalation Technique : A qualitative, explorative study.
    Tameling, C.M.
    Summary Background: Inhalation therapy is the cornerstone of asthma management. However, general inhalation technique is poor: 70-80% of patients do not use their inhalers correctly, which is associated with poor asthma control. Inhalation technique instruction improves the inhalation technique. However, even if patients receive an instruction, 50% still has a poor inhalation technique. There is increasing awareness about this, but while different inhalation instruction methods are being develop....................
    (2016-01-01) Kwaliteit van leven en seksueel functioneren van volwassenen geboren met een blaasexstrofie.
    Wijnsma, R.F.
    Introduction The classic bladder exstrophy (vesicae ectropia) is one of the rare congenital anomalies in the spectrum of the bladder exstrophy-epispadias complex (BEEC), based on a severe form of a midline defect. Literature shows a detrimental effect of the bladder exstrophy on the quality of life and sexual function. This is the first study in the Netherlands to provide an analysis of the quality of life and sexual function. Objective The aim of this study is to provide an overview of the qual....................
    (2015-01-01) Ervaren vrouwen op de lange termijn na behandeling voor mammacarcinoom meer angst dan vrouwen die niet zijn behandeld voor kanker?
    Vrieling, S. (Stephan)
    Aim: The aim of this study is to assess whether women who have been treated for breast cancer with chemotherapy and/or radiotherapy experience more and/or more intense symptoms of anxiety in the long term after treatment than women who weren’t diagnosed with cancer. Material and methods: From a population of nearly 42.000 patients in general practice, 98 patients who have been diagnosed with breast cancer at least five years ago and 65 controls without cancer were selected. From the 98 patien....................
    (2015-01-01) Delirium op de intensive care: de effectiviteit van clonidine en dexmedetomidine bij een haloperidol-resistent delirium.
    Waardenberg, H.C. van
    Context: 1 out of 3 intensive care patients develops a delirium. These patients have a longer ICU/hosptial-stay, have a worse outcome and have an increased chance of cognitive impairment. For these reasons, it is important that these patients receive sufficient treatment. Worldwide, the first choice of treatment is haloperidol. If this is not sufficient enough, other pharmaceutical interventions can be considered, for example 2-agonists. In clinical practice, clonidine and dexmedetomidine are....................
    (2015-01-01) Invloed van Closed-loop communicatie op medicatietoediening, Pilot studie.
    Samul, A.S.
    Introduction: Preventable errors are made in Health care. Most (70%) are due to human error in cooperation and effective communication. These errors are also made during application of medication to patients admitted to the emergency department (ED). A part of effective communication is the closed-loop communication: The message is received, understood and feedback is given. The degree to which effective communication is applied during admittance of patients to the ED and in particular the clos....................
    (2015-01-01) Zorg te koop
    Wildt, Kim de
    Inleiding Dit onderzoek wordt verricht in opdracht van de secretaris van het stafconvent van het UMCG. Het stafconvent werkt binnen het ziekenhuis mee aan het dagelijkse bestuur. Zij is verantwoordelijk voor het waarborgen en bevorderen van de kwaliteit, veiligheid en doelmatigheid van de patiëntenzorg. Methode Het doel van het onderzoek is om aanbevelingen te doen aan het stafconvent van het UMCG ter beoordeling van de huidige zorgcontracten met ziektekostenverzekeraars of deze in overeenste....................
    (2015-01-01) 'Over de dingen die mij gebeuren, wil ik wel geïnformeerd worden'
    Bos, Michelle
    Inleiding Dit onderzoek gaat over de mening van de kinderen wat betreft hun voorbereiding in het Beatrix Kinderziekenhuis, onderdeel van het UMCG. Vanuit het Beatrix Kinderziekenhuis heeft men aangegeven dat ze graag onderzoek willen doen naar de mening van kinderen over de voorbereiding zoals die op dit moment plaats vindt. Methode Dit zal worden onderzocht aan de hand van de volgende onderzoeksvraag: ‘Wat is het perspectief van het kind op de manier van voorbereiding op een ingreep/onderzo....................
    (2015-01-01) Can one stage full-mouth scaling and rootplaning prevent re-infection?
    Meijer, H.F. (Henriette)
    Introduction Periodontal diseases are multifactorial inflammatory diseases of the gingiva in which bacteria, mostly gram-negative anaerobes, are causal. Periodontal treatment focuses on infection control, eliminating or limiting the causal and risk factors. The aim is to obtain a functional, healthy dentition, without any sign of inflammation. Initial periodontal therapy is performed, as the treatment for periodontitis, by scaling and rootplaning (SRP), per sextant or quadrant in multiple sessio....................
    (2015-01-01) Object-Role Modeling: Validation of a database design methodology in the context of an EHR system : Design of a database blueprint
    Martena, Peter
    Background A Large Teaching Hospital in the Netherlands (LTHN) has started a project with an ICT company for the design and implementation of an Electronic Health Record system (EHR) in order to create relatively higher levels of standardization and quality. Methods The EHR focusses on creating applications that are linked to a central database; the LTHN wants to design a database that includes the building blocks for the design of these applications. The goals of this thesis are to convert the....................
    (2015-01-01) Creating a general method for eMeasure development : Developing the process models for eMeasure development
    Laar, P.J.C. van de
    Introduction As a result of the increasing availability of electronic health information and the increasing demand for quality reports on healthcare, HL7developed a standard for the digital representation of quality measures: eMeasures. Unfortunately HL7 did not provide a standard method for developing these eMeasures. A LTHN is in the process of developing an eMeasure system. In this research a general method is developed for creating these eMeasures. Method This is done in three stages. The i....................
    (2015-01-01) Design of the process of developing CDM's with regard to eMeasures : A case study at a large teaching hospital in the Netherlands
    Beukeboom, Rick
    Background Due to the increasing use of electronic patient records and other health care information technology, an increase in requests to utilize the data that comes forth from these is seen. Methods One of these requests relates to the data regarding the quality of care to gain better insights for further improvements in health care. Health Level 7 created a standard to format quality performance indicators in so-called ‘eMeasures’ for effective communication purposes. Results & conclus....................
    (2015-01-01) De evaluatie van de ‘pink en white esthetics’ van een nieuw geheel keramisch implantaat: een follow-up van 0,5 tot 8 jaar.
    Beekmans, D.G.
    Purpose: To analyse the esthetic appearance of a new ceramic implant in the anterior maxilla and to assess the students’ and laypeople’s ability to identify the implant in the mouth. Furthermore to analyse the satisfaction of patients regarding their implant esthetics over various periods of time. Methods: Twenty patients were included in the present study. Inclusion criteria: a flapless, immediately placed Zirconia implant. Two measurements were set for evaluation of the esthetics: one me....................
    (2015-01-01) Measurements of hardness and erosion of enamel at increasing depths.
    Faber, J.E.L.
    Background. The prevalence of erosive wear, especially among youngsters, is growing. Erosive wear is often the result of erosion in combination with abrasion and/or attrition. An erosive attack causes a softened top layer of enamel that is more vulnerable to wear. Research has shown that wear of eroded enamel increases with lower enamel hardness. The hardness of enamel is dependent on local chemistry and 3D composition, it varies over different parts of the enamel crown and decreases from the e....................
    (2015-01-01) Reiniging van gecontamineerd lithium disilicaat.
    Lee, T.N.
    Objectives: The try-in procedure of a ceramic restoration is an important step before it can be permanently cemented. The ceramic surface after etching can be contaminated by saliva during the try-in phase. There are little independent studies on the cleaning efficacy of Ivoclean. This study evaluated the bond strength of lithium disilicate to a composite resin with and without saliva contamination and with and without cleaning using Ivoclean or water. Materials and Methods: Fifteen lithium di....................
    (2015-01-01) De perceptie van rhodium gecoate brackets in vergelijking met ongecoate brackets.
    Oey, L. (Lauretta)
    Aim: The aim of this study is to determine the perception of visual attractivity of rhodium coated brackets by adolescent orthodontic treated patients and their parents or their attendants. Methods: For this study 50 minors (22 male and 28 female) and 50 parents or attendants (17 male and 33 female) were selected at the Orthodontic department of the University Medical Centre Groningen. The participants were shown four pictures of two types of brackets. Both types are identical in shape and siz....................
    (2015-01-01) Onderzoek naar bepalende factoren omtrent de vigerende endocarditisprofylaxe richtlijn.
    Sportel, G.E.Y.
    The purpose of the present study was to answer the key question: what factors are decisive in the consideration of the current endocarditis prophylaxis directive and how do these factors determine the application in dentistry? Therefore, a literature review has been carried out. Factors in balancing the prophylaxis were examined. The social relevance plays a major role, given the high mortality of the disease. The last few years, the prophylaxis directive has been criticized and amended several ....................
    (2015-01-01) Tablet als input device voor het PACS
    Fictorie, Ingmar
    Circa 40 radiologen van het Universitair Medisch Centrum Groningen werken dagelijks op hun werkstation met het Picture Archiving and Communication System (PACS), waarmee ze radiologische afbeeldingen van patiënten kun-nen bewerken (zoals inzoomen of metingen verrichtingen) en beoord elen. De bevindingen worden vervolgens even-eens door hen in het PACS gerapporteerd en opgeslagen. Van elke patient bestaan één of meerdere onderzoeken (studies) met bijbehorende afbeeldingen (series) en een rappo....................
    (2015-01-01) Improvement of bed occupancy in nursing wards; a redesign of the planning an control of the UMCG Beatrix Kinderziekenhuis
    Veldhuis, Thijs
    This thesis provides an analysis of the current planning and control system of nursing wards at the UMCG Beatrix Children’s Hospital (BKZ). Building on its outcomes, suggestions for a redesign are proposed to optimize the bed occupancy while guaranteeing patients patient accessibility to nursing wards in the BKZ. At this moment, the BKZ experiences a low bed occupancy of 71% and a low patient accessibility expressed by 7% misplacements. This is undesired from both cost and service perspective....................
    (2015-01-01) De ervaring van de patiënt met het UMCG
    Vreugt, Floortje
    In dit onderzoek is de ervaring van de patiënt met het UMCG in kaart gebracht aan de hand van verschillende bestaande bronnen. De belangrijkste bron is spiegelbijeenkomsten (36 berichten) en de hieruit geformuleerde thema’s zijn aangevuld met data uit ‘Vertel het ons (+/- 1600 berichten)’, ‘Bent u tevreden over deze pagina? (1579 berichten)’, klachtopvang (408 berichten) en klachtenfunctionaris (359 berichten). De resultaten uit deze data werden alleen op de desbetreffende afdeling g....................
    (2015-01-01) Determinants of quality of life in children referred for asthma to secondary and tertiary line health care
    Klatte, E.M. (Elzien)
    Background: Asthma in children has a known impact on Quality of life (QoL). Measures like QoL are useful indicators to understand the impact of asthma on functional status and wellbeing. Little is known about independent determinants of QoL in children with asthma. Methods: Children referred for asthma were selected from the Electronic Portal for children. Children from the WHeezing Illnesses LEidsche Rijn (WHISTLER) cohort were approached to participate in the EP as healthy controls. All childr....................
    (2015-01-01) Simultaneous Atrial and Ventricular (Reverse) Remodeling in Patients receiving Cardiac Resynchronization Therapy
    Kloosterman, M. (Marielle)
    Cardiac resynchronization therapy (CRT) is an effective treatment for selected patients with advanced heart failure and cardiac dyssynchrony, leading to ventricular reverse remodeling in 50-60% of patients. However, the simultaneous effect of CRT on left atrial (LA) volume is unknown. This study explored the prognostic implications of changes in left atrial volume in combination with ventricular reverse remodeling in patients with either sinus rhythm (SR) or atrial fibrillation (AF). Consecutive....................
    (2015-01-01) Functionele lateralisatie van de supplementaire motore cortex in beeld gebracht met diffusion tensor imaging
    Kok, M.G.J.
    De supplementaire motore cortex (SMC), bestaande uit de supplementary motor area (SMA) en de pre-supplementary motor area (pre-SMA), is betrokken bij het plannen en de initiatie van beweging. De planning, voorbereiding en initiatie van beweging vertegenwoordigen hogere corticale functies die geacht worden dominant te zijn in de linkerhemisfeer, wanneer ze rechtshandigheid ondersteunen door optimale integratie van informatie uit verschillende corticale en subcorticale gebieden. Deze integratie ve....................
    (2015-01-01) MicroRNA, an important regulator of endothelial cell behavior in sepsis ?
    Koster, T.M. (Thijs)
    Background Sepsis is a clinical syndrome which is caused by infection and the subsequent systemic inflammatory response. Despite intensive treatment of the septic patient, the overall mortality of sepsis is unacceptably high, with mortality rates of 20 – 40%. Part of the pathophysiology of sepsis is a hyper inflammatory response of the immune system. Endothelial cells play a role in the inflammatory response, because they recognize pathogens such as LPS, part of the cell wall of Gram-negative ....................
    (2015-01-01) The challenges of pregnancy in patients with systemic lupus erythematosus :Is there a role for hydroxychloroquine?
    Kroese, S.J.
    Introduction: Systemic lupus erythematosus (SLE) is a multisystemic, autoimmune, connective-tissue disease that affects various organs including joints, skin and kidneys. Pregnancy within these patients is a challenge since they are at an increased risk of lupus flares, preeclampsia, spontaneous miscarriage and preterm delivery. The antimalarial drug hydroxychloroquine (HCQ) appears to improve disease activity during pregnancy. The purpose of this study was to investigate the effects of HCQ on l....................
    (2015-01-01) Differences in donor site morbidity between the anterior iliac crest and the calvarium: a case-control study
    Kuik, K. (Karel)
    Background: Due to bone resorption in patients with edentulous jaws, these patients often have problems wearing a denture. A solution is to fix the denture on dental implants, but most of the times there is an insufficient amount of bone left. Often, these patients require the har-vest of autologous bone which is then transplanted to the maxilla or mandible before dental implants can be placed. When a substantial amount of bone is needed, extra-orally harvested bone is required. Autologous bone ....................
    (2015-01-01) TBX4 Mutations in Patients with Pulmonary Arterial Hypertension – Cause or Coincidence?
    Leberkuehne, L (Lynn)
    Introduction: A recent study found a relatively high incidence of TBX4 mutations in patients diagnosed with Pulmonary Arterial Hypertension. This disease is characterized by endothelial dysfunction leading to vascular remodelling, including endothelial-to-mesenchymal transition (EndMT). It is hypothesized that loss of TBX4 causes a disruption in endothelial homeostasis, (i) increasing the susceptibility to develop EndMT and (ii) disrupting the inhibitory pathways activated by laminar shear stres....................
    (2015-01-01) Nutrilon Nenatal Protein Fortifier bij extreme prematuren Het effect van NNPF op groei, tolerantie en (verdenking op) NEC
    Leeuwen, E.M.M. van (Evita)
    Nog altijd bestaat er veel onduidelijkheid over het voeden van prematuren met een extreem laag geboortegewicht. De onrijpheid van het gastro-intestinale stelsel van prematuren zorgt ervoor dat enterale voeding bemoeilijkt wordt. Vanwege de beschermende effecten is moedermelk de voedingsbron van eerste voorkeur voor zowel voldragen als premature neonaten. Echter schiet moedermelk tekort op het gebied van de eiwitbehoefte van een extreme prematuur. Eiwit is een zeer belangrijke voedingsstof als he....................
    (2015-01-01) Predictoren van persisterende of veranderende ontwikkelingsproblemen bij matig prematuren op de kleuterleeftijd
    Lindemuller, L. (Lisanne)
    Doel: Deze studie onderzoekt of er predictoren zijn voor het veranderen of persisteren van ontwikkelingsproblemen bij matig prematuren op kleuterleeftijd. Materiaal & methoden: Er werd gebruik gemaakt van gegevens van de Pinkeltje studie, 641 matig prematuren werden geïncludeerd. Ontwikkelingsproblemen werden gemeten op 4- en 5-jarige leeftijd met de gevalideerde Ages and Stages Questionnaire(ASQ). De uitkomsten van de ASQ op leeftijd 4 en 5 jaar werden met elkaar vergeleken, waarna de deelneme....................
    (2015-01-01) Het effect van neurolyse bij ramus infrapatellaris neuropathie.
    Aalders, W.S.
    Objective: Entrapment neuropathy of the infrapatellar branch of the saphenous nerve is generally an unknown and unfrequently diagnosed cause of knee pain. The aim of this study was to evaluate the efficacy of surgery used by plastic surgeons to treat this neuropathy: neurolysis of the infrapatellar branch. Methods: A cohort of patiënts diagnosed with infrapatellar neuropathy was evaluated. Patiënts that received treatment were asked their pain scores (Numeral Rating Scale 0-10) before and af....................
    (2015-01-01) Early post-transplantation hypophosphatemia and the risk of graft failure and cardiovascular mortality after kidney transplantation.
    Aarts, B. (Brigit)
    Background and objectives Post-transplantation hypophosphatemia, phosphate levels below 0.7 mmol/L, is common after kidney transplantation. Hypophosphatemia is probably the consequence of still elevated levels of fibroblast growth factor 23 (FGF23) and parathyroid hormone (PTH). Long-term exposure to FGF23 and PTH, have been associated with adverse patient and graft outcomes, but may also reflect good graft function. We therefore investigated whether post-transplant hypophosphatemia is associat....................
    (2015-01-01) Stratificatie van STEMI patiënten op basis van biomarkers.
    Al Ali, L.
    Patients who have experienced a myocardial infarction could benefit greatly from custom preventive therapy based on their prognosis. In current practice the estimation of such a prognosis is primarily based on clinical parameters, despite clear indications in available literature that a strong relationship exists between cardiac biomarkers and outcome of cardiac function after an infarction. This retrospective study focused on finding a biomarker driven predictive model for patient prognosis aft....................
    (2015-01-01) De Invloed van Ashy Dermatose / Lichen Planus Pigmentosus op de Gezondheidsgerelateerde Kwaliteit van Leven.
    Bakker, M. (Myrna)
    Background and objectives: Ashy dermatosis (AD) is an uncommon skin pigmentary disorder characterized by ashy-gray macular discoloration of the skin. Some authors categorize AD as a pigmentary macular variant of lichen planus (lichen planus pigmentosus, LPP). However, the etiology is unknown and effective treatment options are not available. The impact of the skin lesions on (health related) quality of life (HRQoL) is unknown. The objective of this study is to assess the HRQoL of patients with ....................
    (2015-01-01) Kinetic changes with fatigue and relationship to running related injuries(RRI) in female runners: a pilot study.
    Bentem, H. van (Han)
    Objectives The incidence of running related injuries (RRI) is fairly high in many recreational runners. Kinetic variables, like the vertical ground reaction force (vGRF), play a possible role in the development of RRI. The purpose of this study was to analyze how treadmill induced fatigue changed the vGRF and spatio-temporal variables of recreational female runners with and without previous RRI. Design Pilot study. Methods Nine recreational female runners with and nine without previous RRI we....................
    (2015-01-01) Voorspellende factoren voor gecompliceerd beloop na hoofdtrauma in de huisartsenpopulatie.
    Berkum, N.J. van (Nicole Juliëtte)
    Background: In primary care, the care and policy for patients with a head injury are based on guidelines of the Centraal Begeleiding Orgaan (Central Body for Guidance) from 2010. At the present time there is no guideline, adapted to the population of patients with a head injury seen by general practitioners, while it is plausible that there are differences in the severity and seriousness of head injury seen in primary and secondary care. Objective: To describe clinical aspects of patients with....................
    (2015-01-01) Predictors for distant metastases in patients with head and neck cancer.
    Blaauw, J. (Jurre)
    Head and neck cancer (HNC) is the sixth most common solid malignancy in the world. Although HNC is considered to be a locoregional disease, in a significant number of patients, survival is highly influenced by the occurrence of distant metastases (DM). Data on risk factors of the presence of DM’s are controversial in the literature; however primary tumor site, T- and N-stage, histology grades and local disease control are considered to be the most important ones. Finding such predictors of DM....................
    (2015-01-01) Voorspelt transcutaan gemeten hypocapnie cerebrale hypoperfusie?
    Bochanen, M. (Margriet)
    Background: premature born children are very vulnerable. They often need respiratory care, which is evaluated by measuring the blood gass value of CO2. These values are obtained by bloodpuncturing, which causes a lot of stress and has several disadvantages. An alternative non-invasive method would be desirable. In this study, we investigated the use of transcutaneous measuring of CO2. It is known that hypocania measured by blood gasses predicts cerebral hypoperfusion. It is not known whether tr....................
    (2015-01-01) Kwaliteit van leven bij patiënten met de ziekte van Parkinson met voorspelbare en onvoorspelbare motorische complicaties
    Boer, A. (Anniek)
    Objective In this study we investigate the influence of motor complications on the quality of life in patients with Parkinson Disease. These motor complications involve on-off fluctuations and dyskinesias which can be predictable or unpredictable. The impact of these motor complications on quality of life is not well understood. There have been little studies on this topic, and these studies show conflicting results. The understanding of this association between motor complications and quality ....................
    (2015-01-01) Preventie van chylothorax als complicatie bij oesofagusresecties.
    Boersma, K. (Karina)
    Background. Postesophagectomy chylothorax is a rare and potentially severe complication in patients diagnosed with oesophageal cancer. It is mostly caused by iatrogenic thoracic duct injury. This complication may be prevented by peroperative visualization of the thoracic duct. In this pilot study we evaluated the effects of peroperative enteral administration of methylene blue in visualizing the thoracic duct. Methods. From 15 October 2014 until 15 January 2015, all patients who underwent an e....................
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