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    (2017-01-01) Implementation of a transcutaneous bilirubinometer in a newborn nursery : A randomized Controlled Trial
    Boer, L. den (Lieve)
    Objective: The aim of this study is to provide quantitative data on the reduction of blood sampling when using transcutaneous bilirubinometry to assess hyperbilirubinemia in healthy jaundiced newborns. Study-design: In a randomized controlled trial in jaundiced infants (≥36 weeks gestational age) in a Dutch newborn nursery ward, the need for total serum bilirubin (TSB) measurement to determine hyperbilirubinemia was assessed by either a transcutaneous bilirubin (TcB) measurement (JM-103) (inte....................
    (2017-01-01) The effect of Deep Brain Stimulation on Corticomuscular Coherence in Parkinson's Disease
    Dijks, J.G.
    Background: In advanced Parkinson’s disease (PD), deep brain stimulation (DBS) is considered as an ultimate treatment; however inefficacy and side-effects remain a challenge. A reliable, non-invasive neurophysiological biomarker could be valuable enabling the application of DBS in a highly selective way. Corticomuscular coherence (CMC) could be used as a potential biomarker. CMC is seen as a representation of the co-operation between brain areas and muscles in motor tasks and is present in PD ....................
    (2017-01-01) The concept of micro-merging within professional services: a case study in the dutch healthcare industry
    Blouw, N. (Nadine)
    Although the literature on mergers and acquisitions (M&As) is quite advanced, analyses of micro-mergers—mergers of internal functional units within the same organization—remain limited. Clarification is needed regarding micro-mergers and their effects on performance. Therefore, this case study investigated micro-mergers within professional service firms (PSFs), specifically focusing on healthcare providers. Thereby, this study addresses the following research question: How do different types....................
    (2017-01-01) Tandartsbezoek en de oudere patiënt
    Ebens, O.E.J.
    People are getting older. Healthy aging and longer living at home is the objective in healthcare and politics. This study looked at the rapidly growing group of independently living elderly people and the factors that affect their dental visit. A questionnaire was sent to 308 patients in a general practice. The response rate was 53%. The study population was satisfied with the accessibility of the dental practice. The majority of the study population regularly came for inspection at the dentist.....................
    (2017-01-01) Morfologisch contourherstel bij directe klasse II composiet restauraties bij het gebruik van verschillende Sectionele Matrixsystemen
    Keulen, G.B. (Gerlof)
    Doelstelling: In deze studie is onderzoek gedaan naar 3 verschillende sectionele matrixsystemen op contour- en contactpuntherstel bij klasse II restauraties. Materiaal en methode: Er zijn in dit onderzoek 3 matrix-systemen getest: het Contact-matrixsysteem, V3-matrixsysteem en het Twinring-matrixsysteem. Met behulp van een kolomboor zijn in 60 KaVo-elementen identieke preparaties gemaakt die in 3 groepen zijn ingedeeld. Per onderzoeksgroep zijn 20 elementen geïncludeerd die at random zijn verde....................
    (2017-01-01) Early feeding habits in relation to oral health in children – a systematic review
    Peters, A.J.F.
    Background Type of feeding during the first period of a child’s life can play an important role in the development of their oral health. The aim of this review was to give an update of available literature on the influence of breast- and bottle-feeding on the development of caries, erosion and the occlusion in children. Methods PubMed was searched for relevant studies published until December 2016. All studies including data on breastfeeding and/or bottle-feeding and their influence on the dev....................
    (2017-01-01) The influence of ultrasonic scalers on the functioning of pacemakers and implantable cardio defibrillators; a systematic review
    Dik, M.E.
    Objectives: The aim of the present study is to systematically evaluate the current literature for the effect of ultrasonic devices, ultrasonic scalers in particularly, on cardiac pacemakers and ICDs to add evidence based knowledge regarding health risks of patients wearing these devices when treated with ultrasonic scalers. Materials and methods: To conduct this systematic review the guidelines for the Transparent Reporting of Systematic Reviews and Meta-analyses were used (PRISMA statement). Th....................
    (2017-01-01) Combination therapy of antithrombin and alpha-1 proteinase inhibitor in a murine model of direct acute lung injury.
    Juschten, J. (Jenny)
    SUMMARY INTRODUCTION Acute respiratory distress syndrome (ARDS) is characterized by hypoxemic respiratory failure following an either direct (e.g. pneumonia) or indirect (e.g. sepsis) pulmonary insult. Dealing with hypoxemia remains the major challenge at bedside and is currently approached with lung-protective mechanical ventilation since specific treatment targeting the pathogenesis of ARDS is lacking. Pathological hallmarks of ARDS are uncontrolled inflammation and coagulation leading to alve....................
    (2017-01-01) Colorectal cancer risk in a nationwide inflammatory bowel disease cohort with indefinite for dysplasia and low grade dysplasia
    Tilburg, S. van (Sanne)
    Introduction: Patients with long-standing colonic inflammatory bowel disease (IBD) bear an increased colorectal cancer (CRC) risk. Endoscopic surveillance allows early detection and removal of precancerous lesions such as indefinite for dysplasia (IND) and low-grade dysplasia (LGD), and may subsequently prevent CRC. However, the long-term outcome after LGD and the subsequent risk to develop CRC remains uncertain, since most available studies are small and cover a relatively short follow-up perio....................
    (2017-01-01) Preformed donor specific antibody class II and its effects on graft outcome after kidney transplantation
    Uffing, A. (Audrey)
    Most kidney transplant centers in the United States of America currently exclude all potential recipients with a donor-specific antibody (DSA), by listing them as unacceptable human leukocyte antigen (HLA) on the deceased donor list. However, the role of preformed DSA class II in graft outcome is not clear and its exclusion significantly reduces the chance of finding compatible donors for highly sensitized patients. In this retrospective cohort, we assessed the effect of preformed donor-specific....................
    (2017-01-01) Verlaging van de loading rate van de verticale grondreactiekracht tijdens hardlopen door middel van feedback: een pilotstudie
    Vrielink, J.W.
    Introduction The rate at which the gound reaction force (vGRF) increases in vertical direction (Loading Rate; LR) seems to be of importance in the onset of running injuries. Runners may experience fewer injuries when the LR is reduced by 10-15%, feedback focused on gait retraining appears to provide such reduction. There are two different types of gait retraining feedback, the first one depends on the information from a person’s own body (internal focus) while the other feedback depends on inf....................
    (2017-01-01) The impact of abdominal infectious complications after T4 coloncancer resection on the development of abdominal recurrences
    Wasmann, K.A.T.G.M.
    Objective: The aim was to characterize the effect of abdominal infectious complications on the development of abdominal recurrences (i.e. local recurrences and peritoneal carcinomatosis (PC)) after curative intent surgery for T4 colon cancer. Background: For decades it is hypothesized that infection-based immunologic pathways create a favorable environment for colon cancer cell dissemination to the abdominal cavity. Despite the prevalence and impact on prognosis of abdominal recurrences, the pat....................
    (2017-01-01) Intra-articular injections of Orthokine reduce symptoms of painand disability in patients with glenohumeral osteoarthritis.
    Aartsen, V.E. (Vivian)
    Introduction. Current non-surgical treatments for glenohumeral osteoarthritis (GH-OA) do not work satisfactorily and tend to focus on reducing pain, not on reducing disability. Autologous conditioned serum (ACS), marketed under the trade name Orthokine, is derived from patients’ own blood and has an anti-inflammatory effect. The primary objective of this study was to determine whether intra-articular injections of Orthokine could reduce symptoms of pain and disability in patients with GH-OA. S....................
    (2017-01-01) Effect of Selective Versus Non-selective α-Blockers on the Hemodynamic Stability in Patients with a Pheochromocytoma
    Alagla, N.
    Background: The use of preoperative α-blockers in patients scheduled for resection of a pheochromocytoma (PCC) is recommended in order to reduce hemodynamic instability and its associated cardiovascular complications during surgery. The choice between non-selective (PXB) and selective (DOX) α-blockers remains controversial. Aim: The aim of this study was to determine the optimal α-blocker for pretreatment of patients with PCC undergoing adrenalectomy. Methods: This interim analysis is part of....................
    (2017-01-01) Rehabilitation of Fine Motor Control in Musician’s Dystonia: Three Days Motor Training With Transcranial Direct CurrentStimulation
    Ampomah, I. (Isabella)
    Introduction: Focal hand dystonia in musicians (MD) is a detrimental neuromuscular disorder that can end musical careers. It´s diverse pathophysiology challenges limited treatment options, and the optimal duration of protocols remains elusive. This study aimed to a) assess the effects of three days transcranial direct current stimulation (tDCS) and training on improvement of hand dexterity and b) reevaluate possible after effects 10 days post intervention. Methods: In this case-control study, p....................
    (2017-01-01) Nieuwe modellen voor het vooorspellen van bijwerkingen na radiotherapie in het hoofdhalsgebied
    Anakotta, A.M.
    Background and purpose: radiotherapy in head and neck cancer can lead to acute and late toxicity. The most common forms of late toxicity (persisting after 3 months), are dysphagia and xerostomia. There is a correlation between toxicity and the dose on organs at risk (OARs). Recently, an international guideline on delineating OARs has been published. The goal of this prospective cohort study was to develop new normal tissue complication probality (NTCP) models based on this guideline for predicti....................
    (2017-01-01) Is de barthelindex bij IC-ontslag voorspellend voor functionele zelfstandigheid op de middellange termijn?
    Arkel, J.J.
    Introduction: The newly introduced interventions in 2013 at the ICU-MCL, targeted at the post intensive care syndrom (PICS), have led to improved functional independence at ICU discharge. Meanwhile ICU length of stay remained unchanged. This paper tries to determine whether this improvement is still relevant 3 months post-discharge, when patiënts visit the outpatiënt department. Materials & Methods: Ranging through 2012-2016 n=289 IC-MCL admissions where included, that lasted >48h and were see....................
    (2017-01-01) Feigning Cognitive Symptoms after TBI: Validation of the TOMM and DCT and the Influence of Coaching
    Schmitt-Monreal, E. M. (Miriam)
    The awareness about the issue of patients feigning their cognitive deficits after traumatic brain injury (TBI) is increasing in neuropsychological assessment. Therefore, tests developed to detect simulated cognitive impairments need to be validated for their integration in standardized assessment procedures. In our simulation study, 114 students from the University of Groningen were randomly assigned to a naïve or coached TBI simulation group and archival data of 43 healthy controls and 22 genu....................
    (2017-01-01) Validating a design methodology for the design of information systems; improving the measurability of performance indicators in hospitals
    Ooserloo, B. (Bianca)
    Healthcare information systems play a critical role in the accessibility of healthcare information that is required for multiple purposes, such as providing treatments of high quality and obtaining insights on healthcare performances. Nevertheless, the success of information systems in healthcare is limited. This research focuses on a design methodology for the design and configuration of information systems in hospitals, to improve the measurability of performance indicators. The design methodo....................
    (2017-01-01) The organization of innovation projects within professional service firms
    Esveldt, L. (Loes)
    This study performs research on how innovation projects are organized within professional service firms (PSF). By combining the two research fields of theory development and academic problem solving, some valuable insights are delivered. PSFs are becoming increasingly important in today’s economy as well as the effective organization of innovation management. However, results show that it is difficult to compare PSFs due to the diverse characteristics between types of PSFs. Innovations within ....................
    (2017-01-01) Logisitiek van medicatie in het UMCG; Onderzoek naar de processen op onderafdeling Klinische Dienstverlening en Assortimentsbeheer
    Lotterman, J. (Jos)
    Summary The unit manager of the Clinical Services & Assortment Management (KDA) feels like the amount of work surrounding the delivery of medication is growing. Because there is no data available to confirm this feeling, the student was asked to research the amount of time that is required in order to deliver a particular type of order, and whether the current number of employees is sufficient to process all the orders. Furthermore, the student was asked to search for possible logistical improve....................
    (2017-01-01) Gezond Gastvrij!; Een adviesrapport voor het creëren van een rookvrije en optimaal gastvrije ontvangst rondom de hoofdingang van het UMCG
    Snijder, R. (Rosanna)
    Managementsamenvatting Ondanks dat een rookverbod geldt voor de hoofdingang van het UMCG, wordt toch in dit gebied gerookt. Hierdoor ontstaan regelmatig klachten bij de gebruikers van het terrein. Deze klachten zorgen er voor dat de gastvrijheid in het gebied rondom de hoofdingang nog niet optimaal is. Het UMCG wil dat elke patiënt, bezoeker of medewerker die via de hoofdingang binnenkomt gastvrijheid ervaart in een rookvrije omgeving. De doelstelling van dit onderzoek is om een advies te gev....................
    (2017-01-01) Informatiebehoefte van ouders in het Beatrix Kinderziekenhuis; Een onderzoek naar communicatie over infectiepreventie en isolatiemaatregelen
    Rademaker, D. (Daniëlle)
    Inleiding Dit adviesrapport presenteert het onderzoek dat ik heb uitgevoerd in opdracht van de sectie Medische Microbiologie en is gericht op het Beatrix Kinderziekenhuis (BKZ). Het centrale vraagstuk draait om het achterhalen van de informatiebehoefte van ouders in het BKZ. De vraag die centraal staat is: ‘Aan welke informatie over infectiepreventie en isolatiemaatregelen hebben ouders in het BKZ behoefte?’ Op dit moment worden ouders niet tot nauwelijks voorgelicht over deze onderwerpen. H....................
    (2017-01-01) SteriNoord: a vicious or virtuous cycle
    Grutters, F. (Frans)
    Well-functioning supply-chains are considered as a competitive advantage. However, the supply-chain of the company that was the subject of this study (SteriNoord) was not functioning well. This was due to the specific type of supply-chain (closed-loop) of SteriNoord in combination with lacking delivery performance. To improve the supply-chain, the delivery performance needs to be increased. This research paper investigated how delivery performance in this supply-chain can be influenced. Four fac....................
    (2017-01-01) Van werkdruk naar werkgeluk
    Veen, W. van der (Wytske)
    Inleiding Vanuit de manager bedrijfsvoering van de afdeling Reumatologie en Klinische Immunologie van het Universitair Medisch Centrum Groningen is de vraag gekomen om het werkgeluk op de deze afdeling te onderzoeken. Momenteel is er in mindere mate sprake van werkgeluk. Dit is ook naar voren gekomen tijdens het laatste medewerkerstevredenheidsonderzoek (MTO). Daarnaast is er onderzoek gedaan op de afdeling Kaakchirurgie. Deze afdeling had bij het laatste MTO de hoogste score van alle poli’s. ....................
    (2017-01-01) Ontspannen in VR; het ontwerpen van een VR game om relaxatie bij patiënten met matige psychotische klachten te bevorderen
    Bakker, R. (Rowin)
    Abstract: Het UCP (Universitair Centrum Psychiatrie) van het Universitair Medisch Centrum Groningen (UMCG) is vorig jaar, onder leiding van psychiater en onderzoeker dr. Wim Veling, gestart met een virtueel relaxatieproject. Dit project, VRelax, bestaat uit rustgevende 360° video’s. Patiënten met verschillende psychiatrische diagnoses zijn met het VRelax programma in een pilotstudie getest op de mate van ontspanning en gemoedstoestand. Uit de resultaten van de pilot bleek dat de deelnemers n....................
    (2017-01-01) Van werkdruk naar teamgeluk
    Veldsema, A. (Annerie)
    Eens in de vijf jaar wordt er binnen het UMCG een onderzoek naar de belevingen van medewerkers uitgevoerd. De afdeling Reumatologie en Klinische Immunologie scoorde in het onderzoek van 2012 onvoldoende. In de jaren daarna is er geprobeerd de beleving te verbeteren, maar tot nu toe nog zonder succes. Deze beleving kan worden omschreven als teamgeluk. De doelstelling van dit onderzoek is om op zoek te gaan naar de kritische succesfactoren voor teamgeluk. De centrale vraag die hierbij is geformu....................
    (2017-01-01) A planning and control framework for residents' activities
    Olsder,W. (Wendy)
    Problem statement and research objective: Medicine residency is a challenging graduate medical training in which residents (in Dutch: AIOS: ‘Arts in Opleiding tot Specialist’) are exposed to one of the medical specialties. During the residency program, residents are considered both learners and providers of medical services. Many university medical centers face a difficult challenge of designing feasible schedules for their residents, because the schedules need to satisfy both the educationa....................
    (2017-01-01) De agenda zit vol, toch?; Een onderzoek naar de lange toegangstijden op de polikliniek Neurologie in het UMCG
    Reitsema, B. (Bauke)
    Dit onderzoek is uitgevoerd in het Universitair Medisch Centrum Groningen (UMCG) op de polikliniek van de afdeling Neurologie. Er is op de polikliniek sprake van een volle agenda en er ontstaan lange toegangstijden. De doelstelling van het onderzoek is om inzichten te geven in mogelijke oorzaken van de lange toegangstijden om vervolgens aanbevelingen te kunnen geven waardoor de toegangstijd mogelijk kan worden gereduceerd. Het is een zowel een beschrijvend onderzoek als een exploratief onderzoek....................
    (2017-01-01) The influence of face-to-face communication on intergroup interaction and attitudes
    Tönis, N. (Noortje)
    Introduction How multidisciplinary teams collaborate and communicate with each other is essential to both patients and employees. Healthcare information systems are being implemented at outpatient clinics on a large scale and will continue to be developed in the future. These communication technologies offer visible benefits regarding the quality of healthcare, but their effects on intergroup interactions are underexplored. Therefore, the aim of this study is to investigate the influence face-to....................
    (2017-01-01) Succesvol langer doorwerken, een gezamenlijke verantwoordelijkheid
    Scholten, F. (Fleur)
    Inleiding Dit onderzoek is gestart naar aanleiding van vragen en onzekerheid over de verhoogde AOW leeftijd. Men moet langer doorwerken, maar hoe gaan we dat succesvol samen doen? Hieruit zijn de volgende vragen tot stand gekomen: Deelvragen: “Wat is de invloed van succesvol langer doorwerken van de analisten en doktersassistenten van 55 jaar en ouder, met betrekking tot de factoren: Ability, Motivation en Opportunity to participate. Hoofdvraag: “Welke factoren ondersteunen het succesvol l....................
    (2017-01-01) Clinical lymph node staging and impact on different treatment options in esophageal cancer
    Dijksterhuis, W.P.M.
    Background: Accurate clinical nodal (cN) staging in esophageal cancer (EC) remains difficult. Prognostic impact of nodal over- and downstaging on 5-year disease-free survival (DFS) and predictability of response were assessed in EC patients after surgery alone or after neoadjuvant chemoradiotherapy (nCRT) followed by surgery. Patients and methods: From a prospectively maintained database, we included 395 consecutive patients with curative intended esophagectomy after or without nCRT between 2000....................
    (2017-01-01) A home-made method for human papillomavirus detection in head and neck cancers
    Fazzi, M. (Maran)
    Abstract: Since the beginning of this century it has become clear that, besides cervical cancer, human papillomavirus (HPV) is causing a subset of other cancers, among which are oropharyngeal squamous cell carcinomas (OPSCC). The incidence of HPV related OPSCCs is rising and it is estimated that its incidence will exceed the one of HPV related cervical cancer in 2020. HPV related OPSCCs respond better to treatment and have a better prognosis than HPV negative OPSCCs. That is why it is important ....................
    (2017-01-01) De rol van de opleiding tot professional in de samenwerking tussen artsen en verpleegkundigen
    Molema, M. (Myrna)
    Inleiding Een goede samenwerking tussen artsen en verpleegkundigen is van belang voor de kwaliteit van zorg en de tevredenheid van verpleegkundigen en artsen (Baggs & Ryan, 1990; Baggs, 2007; Zwarenstein, Goldman, & Reeves, 2009). Uit onderzoek blijkt dat een grote meerderheid van artsen en verpleegkundigen vindt dat de huidige samenwerking beter kan (Neggers, 2008). In dit onderzoek is onderzocht of de opleiding tot professional een rol speelt in de kwaliteit van de samenwerking tussen artsen ....................
    (2017-01-01) Barriers and Facilitators for Timely Linkage to HIV Care in Curaçao, and Recommendations for Targeted Public Health Interventions
    Baekelandt, E.R.F. (Elisabeth)
    After sub-Saharan Africa, the Caribbean region has the highest HIV prevalence in the world. In Curaçao, the HIV incidence has continued to rise over the years. Plans are in place to introduce universal testing, followed by treatment with the aim of reducing viral transmissions. However, for this public health intervention to be effective, there needs to be adequate linkage to and retention in HIV care. Current evidence suggests that people living with HIV in Curaçao have poor linkage and reten....................
    (2017-01-01) The predictive value of left ventricular hypertrophy on ECG for cardiovascular outcome in the Thai population
    Bakker, J. (Joanne)
    Background: In Thailand, the prevalence of cardiovascular disease (CVD) increased excessively during the past decades and is the leading cause of death. Left ventricular hypertrophy (LVH) can be seen on electrocardiogram (ECG) and is associated with poor cardiovascular outcome, but no incremental predictive value is seen when putting LVH in a traditional predicting model. Most studies on this specific subject were performed in Western populations. However, because Asians have a higher prevalence....................
    (2017-01-01) Long-term outcome after pelvic and acetabular fractures : Does age matter?
    Banierink, H. (Hester)
    Background. Fractures of the pelvis and acetabulum are serious injuries, mostly caused by high-energy traumas or due to osteoporosis in the elderly. The fracture type varies from a simple fracture with no instability of the pelvis, to life-threatening “open book” fractures. The ring structure of the pelvis makes isolated fractures rare and gives a high risk of associated acetabular fractures. Pelvic and acetabular fractures can be treated either conservatively or surgically, depending on the....................
    (2017-01-01) Prenatal screening for congenital abnormalities: role of the 13 week scan
    Bardi, F. (Francesca)
    Background and aim The primary aim of this study is to determine the percentage of fetal congenital abnormalities found at the 13 week gross-anatomy survey performed in concomitance of the dating scan or the combined test (CT). Secondly, the research investigates how many and which of the defects observed at the 20 week anomaly scan were not identified by the ultrasound scan performed earlier in gestation. Methods This is a retrospective study performed on a prospectively collected database of c....................
    (2017-01-01) T cell phenotype in end-stage renal disease patients
    Bastiaansen, M.A.J.
    End-stage renal disease (ESRD) is a major health problem and associated with significant morbidity and increased mortality, due to a higher risk of infections and cardiovascular diseases. The high levels of uremic toxins lead to the dysregulation of the immune system, in which T lymphocytes play a central role. Before starting with a big cohort, a pilot study is needed to optimizing the protocol and looking to differences in T lymphocytes between healthy controls and dialysis patients. We lookin....................
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