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University of Groningen Digital Archive

Browsing University of Groningen: Mathematics and natural sciences

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    (2017-01-01) Artefacts in carbonaceous aerosol sampling
    Kooijinga, J.F.
    De begeleider en/of auteur heeft geen toestemming gegeven tot het openbaar maken van de scriptie. The supervisor and/or the author did not authorize public publication of the thesis.
    (2016-01-01) A smart elevator for Zernikeborg
    Tanis, J
    De begeleider en/of auteur heeft geen toestemming gegeven tot het openbaar maken van de scriptie. The supervisor and/or the author did not authorize public publication of the thesis.
    (2016-01-01) Networked Control under Denial-of-Service
    Keulen, G.A. van
    De begeleider en/of auteur heeft geen toestemming gegeven tot het openbaar maken van de scriptie. The supervisor and/or the author did not authorize public publication of the thesis.
    (2016-01-01) Logistieke optimalisatie van CIG Centraalstaal
    Loeffen, J.E.G.P.
    De begeleider en/of auteur heeft geen toestemming gegeven tot het openbaar maken van de scriptie. The supervisor and/or the author did not authorize public publication of the thesis.
    (2016-01-01) Maintenance (process) improvement
    Koopman, B
    De begeleider en/of auteur heeft geen toestemming gegeven tot het openbaar maken van de scriptie. The supervisor and/or the author did not authorize public publication of the thesis.
    (2016-01-01) Collective sensing: How animal groups scale noisy gradients
    Couzin, I. D.; Weissing, F.; Sridhar, V. H.
    In the natural world, individuals constantly face the challenge of acquiring, interpreting and responding to complex sensory information. This is especially challenging when in- dividuals must navigate heterogeneous environments. Recent empirical evidence suggests that animals may deal with this challenge by living in groups and processing information collectively. While these collective properties are manifested at a group level, they are an outcome of decisions made by individuals. In general,....................
    (2016-01-01) Excited State Spectroscopy and Optical Bleaching in c-axis divacancies in Silicon Carbide
    Adema, J.A.H.
    C-axis divacancy bound electron spins in Silicon Carbide (SiC) have interesting properties for quantum information applications. SiC is a material well known to large scale industrial processing and spin states in the ground state of the divacancy show coherence times (T2 ∗) up to the millisecond scale. This thesis addresses two main issues regarding optical manipulation ensembles of c-axis divacancies in SiC: the process of charge state switching (optical bleaching and repumping) and the yet ....................
    (2016-01-01) DimRedPlot: A Generic Visualisation Tool for Dimensionality Reduced Data
    Winter, K. L.
    Dimensionality reduction techniques can transform datasets with a large number of variables to simpler two or three-dimensional datasets, while preserving distances and structure in the original data as much as possible. This makes these techniques very useful when dealing with large datasets. Unfortunately, the results they produce can be abstract, making it hard to fully understand how these results relate to the original data. As a result, many researchers treat these techniques as simple bl....................
    (2016-01-01) Neural Activity in Response to Food Images is Mediated by the ASB9 and DNM3 Gene and is Associated with Methylation and Ghrelin.
    van der Kamp, C.H.
    Gaining insights in how genetics influence obesity, brain activity, and eating behavior will add important knowledge for developing strategies for weight-loss treatment, as obesity may stem from different causes and as individual feeding behavior may depend on genetic differences. To this end, we have examined if the ASB9, DNM3 and RSPO04 gene affects neural activity via fMRI when individuals are presented with images of food. Recently five DNA methylation sites related to BMI have been discover....................
    (2016-01-01) The role of vitamin D in asthma and the effect of supplementation
    Oude Avenhuis, M.
    Vitamin D deficiency is a global public health issue and has been associated with an increased incidence and severity of many diseases including diseases of the respiratory system. Due to westernized lifestyles, with spending more time indoors, there has been an increase in asthma and allergy as a result of vitamin D deficiency. Asthma is a chronic inflammatory disease of the lungs and the number one chronic disease in children. The vitamin D receptor (VDR) is expressed in cells involved in the ....................
    (2016-01-01) Sparse Inference of High Dimensional Survival Models
    Velt, V
    This thesis concerns sparse inference of high dimensional survival models. By describing the statistical model space as a Riemannian manifold, we discuss the geometrical structure of generalized linear models. Then we use this geometrical interpretation to find a sparse solution path that leads to the maximum likelihood estimator. The method we suggest to find such a sparse solution path, is based on differential geometric least angle regression. For the purpose of this thesis the method is exte....................
    (2016-01-01) Mitochondrial dysfunction in humans by cyto-nuclear incompatibility
    Beukeboom, L.W.; Lusseveld, J.H.
    Mitochondria provide energy for the cell by using sugars and lipids and converting stored energy in the form of a proton gradient into usable ATP. Mitochondria are also responsible for calcium signalling, cell metabolism regulation, steroid synthesis and apoptosis. Mitochondrial proteins are mostly encoded by nuclear DNA (nDNA), but mitochondria also have their own DNA (mtDNA). This mtDNA is 17 kb long circular double stranded DNA, and has a high mutation rate because of its proximity to oxidati....................
    (2016-01-01) Synthesis and investigation of copper-oxo-selenides
    Haas, W. B. de
    De begeleider en/of auteur heeft geen toestemming gegeven tot het openbaar maken van de scriptie. The supervisor and/or the author did not authorize public publication of the thesis.
    (2016-01-01) Incommensurate magnetism in PrBa2Cu3O6+x
    Boer, M.H.
    De begeleider en/of auteur heeft geen toestemming gegeven tot het openbaar maken van de scriptie. The supervisor and/or the author did not authorize public publication of the thesis.
    (2016-01-01) Mudfold: A nonparametric Item Response Theory model for unidimensional unfolding
    Balafas, S.
    Preferences, choices and attitudes are observations which are modelled in Statistics with the use of latent variables. These variables are not directly measurable and their values are obtained from other indicator variables called items. The study which handles and analyzes the responses from a population to a set of items in a statistical context, is known as Item Response Theory (IRT). MUDFOLD (Multiple UniDimensional unFOLDing) is a nonparametric model in the class of Item Response Theory mod....................
    (2016-01-01) Using a smartphone game to promote transfer of skills in a real world environment.
    Doesburg, I.
    This article presents an experiment in which participant’s working memory, tasks-switching and focusing skills are trained in a game called Wollie on a smartphone. A control group trained with a smartphone version of Tetris, which trained no particular cognitive skills. Participants played their game for at least 10 minutes a day for two weeks. Before and after the training period they performed three task (a recall, Stroop and task-switching task). The goal of this research was to see how the....................
    (2016-01-01) Distracted by the self: Measuring and modeling distraction by self-referential processing in a complex working memory span task
    Daamen, J.A.
    This study attempted to measure and model distraction caused by self-referential processing (SRP) on a memory task. Two experiments using novel complex working memory span tasks were performed, both required the participants to remember a span of letters whilst being distracted by the processing of words. In the first experiment the recall score after SRP (i.e. “Does this word describe you?”) was compared to the score after a non-SRP task using the same words (i.e. “Does this word contain ....................
    (2016-01-01) The Non-Convicted Psychopath
    Rigter, P.M.F.
    Psychopathy is a well-investigated topic that describes the personality disorder that is characterised by low empathy, impulsive and antisocial behaviour. Research within psychopathy is mainly done on convicted individuals that are incarcerated, and only little research has been done on individuals with high psychopathic tendencies that have never been convicted – the non-convicted psychopaths. This thesis investigates whether there is a difference between the non-convicted psychopath and conv....................
    (2016-01-01) The causes and consequences of depression on a neurological level
    Bodha, P.K.
    Every year, the number of people diagnosed with depression increases with 20%. Several forms of depression are known, each with their own specifities and symptoms, making diagnosis hard. Depression can have severe effects on an individual’s personal life, work and overall health. In most of the cases, this condition can be treated by a combination of psychotherapy and medications such as antidepressants. In severe cases of depression, electroconvulsive therapy or deep brain stimulation can be ....................
    (2016-01-01) Localization of fabricated kits
    Vedder, G
    The research was done at CIG – Centraalstaal. Headquartered in the Netherlands, CIG Centraalstaal supplies aluminium and steel building kits for a wide variety of applications ranging from shipbuilding to complex architectural projects. The factory where the parts are fabricated, places these on pallets when they are smaller than 250 cm. The pallets with finished products are currently stored on the area near the factory. A forklift driver picks up the pallets and places these on an arbitrary ....................
    (2016-01-01) Essay: Mechanisms that lead to aneuploidy in cells and its link with cancer
    Borneman, A
    For growth and repair already existing cells need to duplicated. This is accomplished through a sequence of events, known as the cell cycle. The cell cycle is tightly controlled by a number of checkpoints, like the spindle assembly checkpoint, to ensure that the duplication and segregation of the chromosomes occur correctly. Defects in cell cycle regulation can cause chromosome missegregation and aneuploidy. Mechanisms like centrosome amplification and merotelic attachments are observed in cance....................
    (2016-01-01) The role of secreted cellular factors after DNA damage in the development of senescence and the treatment of cancer
    Visser, N
    According to the World Health Organization (WHO), cancer is the leading cause of death worldwide. When DNA damage is not repaired, this will lead to lesions which can cause cancer. The DNA damage response (DDR) is a complex mechanism which includes DNA repair systems and checkpoints which detect the lesions. If a lesion is detected, than this mechanism will secrete signals which activates DNA repair. An important mechanism to permanently prevent proliferation in damaged cells is called cellular ....................
    (2016-01-01) Nutrition and the glial response in Multiple Sclerosis
    Dietz, L.E.R.
    Multiple Sclerosis (MS) is a demyelinating disorder of the CNS. The disease is characterized by the loss of myelin, neurodegeneration and inflammation. The glial cells, astrocytes and microglia, are thought to be important contributors to the pathology of MS, although it is not sure in what way. Both are thought be important during remyelination, through myelin clearance and orchestrating the remyelination process. Nutrition could affect the progress of remyelination through influencing these in....................
    (2016-01-01) Genotyping of CYP2C19 helps to reassure sufficient effects of antiplatelet therapy in combination with proton pump inhibitors (PPIs)
    Boekema, P.H.
    Clopidogrel therapy in combination with proton pump inhibitors (PPIs) is controversial in the treatment for ischemic heart diseases after coronary stent implantation because PPIs (especially omeprazole) are suggested to attenuate the antiplatelet effect of clopidogrel. The polymorphic CYP2C19 enzyme has a pivotal function in the metabolism of both agents. In addition, omeprazole can irreversibly inhibit the activity of CYP2C19 enzyme. The frequency of CYP2C19 polymorphisms with a poor metabolize....................
    (2016-01-01) Essay: Vancomycin Heteroresistance in Staphylococcus aureus
    Dirkzwager, M.N.
    Bacterial heteroresistance is the presence of small amounts of bacterial cells within a population that have an increased resistance to antibiotics (i.e. an increased MIC). When exposed to an antibiotic these cells have a competitive advantage and are more likely to survive and give rise to a more resistant population. This can be especially problematic in clinical infections, where it is thought to be a cause of treatment failure and has been associated with increased patient mortality. Heteror....................
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